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About one out of every 33 people tested will learn they have an actionable genetic 
risk factor1

Many people aren't aware that they carry a variant risk for an inherited condition — for many they do not experience symptoms and don’t know they are at risk. GenePrism tests for 59 genes that can significantly impact your health; empowering you to take steps towards more informed health choices.

Alzheimer's ApoE

by ADx Healthcare

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Health professionals

Your health is important, so are your choices with Helix

In the fight against late-onset Alzheimer’s disease, early awareness can make a difference in taking care of your future self. A consultation with a genetic counselor is included to help you better understand your risk.

Price of this test includes $35.00 paid to the service provider for physician approval and genetic counseling services.


$199.99
Price of this test includes $25.00 paid to the service provider for physician approval and genetic counselling services.
To use Helix, you must be 18 or older and have a U.S. shipping address. Not available for residents of Alaska, Arkansas, Delaware, Idaho, Nevada, and New York.
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What is Alzheimer's disease?

Alzheimer’s disease is a progressive form of dementia that is characterized by tau proteins and plaques in the brain that result in brain cell death over time. Scientists believe that for most people the development of Alzheimer’s disease is caused by a combination of genetic, lifestyle, and environmental factors

Why learn more about your risk?

Research indicates that lifestyle behaviors across your life span may contribute to the development of Alzheimer’s disease.

Also, changes occur in the brain up to two decades before the first symptoms develop. Because Alzheimer’s is believed to be caused by a combination of environmental, genetic, and lifestyle factors, learning your genetic risk can help you determine how aggressively you need to make lifestyle changes to reduce your risk.

The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Alzheimer’s disease.

Product summary

Genetic Alzheimer's Test is for anyone who is curious about their possible genetic risk for Late-Onset Alzheimer's Disease. This test is not for individuals who currently have symptoms of Late-Onset Alzheimer's Disease or have a strong family history.

What you'll learn

Genetic Alzheimer's Test can tells you how a single gene, ApoE, influences your risk for Late-Onset Alzheimer's Disease and how the risk for Late-Onset Alzheimer's Disease changes with age.

You'll also learn how your risk compares to the risk of the general population and learn helpful recommendations for lifestyle changes to improve your cognitive health.

What's included

Helix DNA kit

Helix DNA kit to get your DNA sequenced and stored. Learn more

Acme Corp

The Genetic Alzheimer's Test.
View your results on iOS or web.

Review from licensed physician

Review from licensed physician for approval.

Genetic counselling

Genetic counselling to answer your questions.

Why get tested?

Genetic Alzheimer’s Test is a single gene test that looks at the ApoE gene. This gene can have a significant impact on a person’s odds of developing Late Onset Alzheimer’s Disease, by either lowering or rasing your odds. You will learn whether you have the version of ApoE that raises or lowers your risk.

Late-Onset Alzheimer’s Disease

Alzheimer's is the most common cause of dementia, a general term for memory loss and other cognitive abilities serious enough to interfere with daily life most commonly affecting people over the age of 65.

Learn more

The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Alzheimer’s disease.

What will my results tell me?

Your test results will explain which version of ApoE you have. There are three versions, or alleles, known as e2, e3, and e4. e2 lowers the odds below the general population risk, e3 has no impact, and e4 raises your risk for developing Late Onset Alzheimer’s Disease. Your results will explain which combination of ApoE alleles you have.

Lower than average risk

At least one copy of ApoE-e2 and no copies of ApoE-e4 has been detected. This lowers your odds but not to zero. Continue with screenings recommended by your health care provider.

View a sample report for lower than average risk

Average risk

Two copies of ApoE-e3 has been detected. It's important to continue with any other screenings your healthcare provider recommends.

View a sample report for average genetic risk

Higher than average risk

At least one copy of ApoE-e4 has been detected. Individuals with the high risk ApoE-e4 variant should seek their physician’s assistance.

View a sample report for high than average risk

The science

  • What we look for
  • Understanding risk
  • Test details
  • Limitations
  • References

What we look for

We look for two common alleles in ApoE, the gene most strongly associated with Late-Onset Alzheimer’s Disease risk. Based on these two versions, we are able to determine if you have copies of the lower odds (e2) or higher odds (e4) alleles. Having the higher odds allele does not guarantee that you will develop Alzheimer’s disease. Likewise, possessing a copy of the lower odds allele does not mean you won’t develop Alzheimer’s disease.

The test only looks for two known alleles in ApoE. This test does not include any other alleles for Late-Onset Alzheimer’s Disease, nor does it include variants associated with Early-Onset Alzheimer’s Disease.

View white paper

Understanding risk

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Test details

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Overview of test performance (table)

Studies Results Score

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95%

confidence level

Accuracy

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100%

Sensitivity

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99.9%

Specificity

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96%

PPV

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100%

Limitations

Genetic, environmental, and lifestyle factors all contribute to an individual’s risk for cardiovascular
disease.

Results from this product are designed to be used in consultation with a healthcare provider.

Our understanding and interpretation of the relationship between specific genetic variants and
disease risk will develop as the science evolves.

This test does not cover all cardiovascular conditions or all genes related to cardiovascular
conditions.

References

1 Lazonao P. et al., “Evidence Summary: Screening for Familial Hypercholesterolemia: Other Supporting Document for Lipid Disorders in Children and Adolescents: Screening,” JAMA 316, no. 6 (2016): 645-655. doi: 10.1001/jama.2016.6176.

2 FH Foundation. “What is FH?” Accessed July 22, 2017. www.thefhfoundation.org/about-fh/what-is-fh.

3 Bouhairie, Victoria Enchia and Anne Carol Goldberg. “Familial Hypercholesterolemia.” Cardiology Clinics 33, no. 2 (2015): 169-179. doi: 10.1016/j.ccl.2015.01.001

Guided by health professionals

Because this test screens for conditions that might have serious medical implications, ACME Corp provide health guidance every step of the way.

Physician reviewed

Since the test analyzes conditions that might have serious medical implications, Genetic Alzheimer’s Test will have an independent doctor review your health history to ensure this test is right for you.

Genetic counselor supported

You talk with one of ACME Corp’s licensed, board-certified genetic counselors at no additional charge. Your genetic counselor can review your results and discuss what they mean for you.

5 SIMPLE STEPS

How it works

In order to use Genetic Alzheimer’s Test, you will have your DNA sequenced by Helix. You'll only have to do this once—no matter how many Helix-powered products you use in the future.

Step 1

Receive Helix DNA kit

Helix will send you a DNA collection kit to get you on to the road of DNA insights. Depending on the product, you may also receive a blood sampling kit.

Step 2

Provide your health history

Depending on the product, you may be asked a few questions about your health history, which will be reviewed by a physician to ensure the product is right for you.

Step 3

Send kit back

Once you’ve completed and registered 
your DNA kit, mail it back with our 
pre-paid postage.

Step 4

Receive Helix DNA kit

Helix will send you a DNA collection kit to get you on to the road of DNA insights. Depending on the product, you may also receive a blood sampling kit.

Step 5

Provide your health history

Depending on the product, you may be asked a few questions about your health history, which will be reviewed by a physician to ensure the product is right for you.

Questions

  • What form of Alzheimer’s disease does this test for?

    The Alzheimer’s ApoE Test will help people determine their genetic risk for the most common form of the disease: non-familial (“sporadic”) Alzheimer’s.

    By contrast, when people talk about the “hereditary” or “familial” form of Alzheimer’s disease, they are usually talking about a very rare form of the disease (only about 1% of all cases) that is caused by an abnormality in one of three specific genes – PS1, PS2, or APP. This form is also referred to as early-onset familial Alzheimer’s disease (eFAD). This is not the form we’re talking about with ApoE testing. ApoE is a risk factor for the non-familial (also called “sporadic”) form of Alzheimer’s disease, which is the most common form of the disease.

  • Do I have to get sequenced to use this product?

    Yes. In order to use the Alzheimer’s ApoE Test by ADx Healthcare, you must be sequenced by Helix. To ensure the quality and accuracy of the genetic information used for this service, products in the Helix marketplace do not accept genetic data from outside sources. And, once you’ve been sequenced by Helix, you can purchase more DNA-powered products from a variety of categories like fitness, nutrition, entertainment, and more—all without having to get sequenced again.

  • How does Helix provide my DNA information to ADx Healthcare? Is it shared with anyone else?

    Your DNA information is stored securely by Helix. When sequencing is complete, Helix only sends the relevant DNA information needed by ADx Healthcare to generate your results. We do not share your DNA information with anyone without your permission. We always maintain high standards when it comes to the security and privacy of your DNA information.

  • How do I learn more about how ADx Healthcare uses my information?

    You can learn more in the ADx Healthcare Privacy PolicyTerms of Service, and Product Consent.

  • Can I choose my own physician to approve testing?

    No. When you order Alzheimer’s ApoE Test, you answer relevant health history questions. Helix will share your contact information and health history with ADx Healthcare so a physician they designate can review and make sure this product is right for you. This process helps make sure you get access to these insights quickly and efficiently through a provider that is familiar with this type of testing. You can always share your results with your healthcare providers.

  • Do I need access to my medical records to answer the health history questions?

    While it might help to have your records handy, it’s definitely not required. It’s okay to answer the health history questions from memory to the best of your ability.

  • Can I use my health insurance benefits to purchase this product?

    Unfortunately, no. This is an at-home test that doesn’t require an office visit, and we cannot currently accept payment from insurance providers.

  • Will someone be available to help me understand my results?

    You will receive your test results in a clear report. However, if you have additional questions about what the results mean to you or your family, we have independent genetics counselors available to discuss your results with you, for no additional charge. Also, we encourage you to share your report with your physician and review with them any additional questions or concerns you may have.

  • What genes does this product check?

    The Alzheimer’s ApoE test is a single gene test that looks at your ApoE-related genetic risk for Alzheimer’s disease. There are other genes that play a role in Alzheimer’s risk but the ApoE gene is believed to be the largest contributing genetic factor. Having a high risk copy of this gene (ApoE-e4) does not guarantee that you will develop Alzheimer’s disease. Likewise, possessing a copy of the lowest risk variant (ApoE-e2) does not mean you won’t develop Alzheimer’s disease. Alzheimer’s disease risk is also influenced by other genes, other medical conditions, age, gender, and environmental and lifestyle factors, so learning your ApoE-related genetic risk is only one part of an assessment of risk. Knowing your overall risk can help you decide how aggressively you want to address your cognitive health.